It really comes down to what kind of failure you are trying to protect against. A standard Galera Cluster usually operates within a single region to provide local high availability and fault tolerance. It is great for protecting against individual node failures, but if that entire data center goes offline, your app goes with it.
A multi-region cluster spans different geographic areas, which protects you from regional outages and disasters. It also helps with global performance because you can route users to the node closest to them. Platforms like AccuWeb.Cloud offer these geo-resilient architectures using pre-built templates, making it much easier to deploy across continents than doing it manually.